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Regulatory T-cell and neutrophil extracellular trap interaction contributes to carcinogenesis in non-alcoholic steatohepatitis

"Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes: a randomised, double-blind, placebo and active-controlled, parallel-group, phase 2 trial conducted in the USA." The Lancet , 2023

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This story mentions GLP-1 drugs, which are FDA-approved for weight management in adults diagnosed with obesity or with overweight and at least one weight-related health condition

Red flags requiring immediate evaluation include severe abdominal pain (possible pancreatitis), persistent vomiting leading to dehydration, suicidal thoughts, development of new eating disorder behaviors, syncope, chest pain, hematemesis/melena, severe constipation/obstipation, orthostatic hypotension, or marked electrolyte abnormalities

Was it topical, injected, or part of a stack