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Local administration is commonly used because its effects appear strongest close to the target tissue

The NICE guidelines on obesity management do not include B12 supplementation as a therapeutic option for weight reduction in the absence of documented deficiency

(2009) Cognitive and psychiatric effects of vitamin B12 replacement in dementia with low serum B12 levels: a nursing home study

These shots can boost B12 levels, giving faster results in energy and metabolism

**Lower cost** AOD-9604 was historically cheaper than GLP-1 medications However, the clinical reality is that AOD-9604 failed its pivotal weight loss trial

One such study in 2012, published in the journal Obesity, found that obese individuals who received vitamin B12 injections lost an average of 3 pounds more than a placebo group over 12 weeks