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Je mehr reduziertes Glutathion in der Zelle ist, desto belastbarer ist sie

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Thus, depletion of intracellular GSH is considered a potential solution to boost the efficacy of chemotherapy and ROS-based therapy, including PDT, SDT, CDT, ferroptotic therapy, and radiotherapy

In some studies, Vitamin E supplementation has been shown to normalize depleted Glutathione levels

Most of the mutations are leaky so that many patients have residual enzyme activity