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In individuals with normal B12 metabolism and no ongoing deficiency, the body's stores can theoretically last several years

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The review also noted that GHK-Cus copper complexation ability raises Cu2+ penetration rates across the stratum corneum, and documented the development of formulation innovations including the TriHex peptide system that combine GHK-Cu-type tripeptides with hexapeptides to produce synergistic upregulation of regenerative genes and suppression of aberrant collagen deposition

Russian preclinical literature is the main evidence base

Vitamin B12 deficiency has been associated with partially reversible optic neuropathy in some children with autism (Pineles etal, 2010), and potentially could explain the increased risk of optic neuropathy in children with autism (Chang etal, 2020) Vitamin B12 is involved in the production of choline, which is the precursor for acetyl choline

Financially, you should know that peptides like 5-Amino-1MQ are not covered by insurance