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While those Phase I and II drug-metabolizing enzymes are mainly expressed in the liver, it was demonstrated recently that a wide variety of the enzymes are expressed in human skin 35
These metabolic shifts often persist even if a patient temporarily pauses the medication, suggesting durable physiological change rather than temporary fluid loss or muscle depletion
135 , e194751 (2025)
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Conjugation of a fatty acid chain via hydrophilic linkers to lysine residue at the C20 position prolongs its half-life and enables onceweekly subcutaneous administration [62]
