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However, the precise enzymatic machinery responsible for Kla deposition and removal remains incompletely characterized and the relative contributions of enzymatic vs
New Engl J Med (2017) 377(1):1327
Results should be interpreted together with the medication history
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Recent enzymatic analyses in lymphocytes showed that BD patients in the depressive phase had lower levels of mitochondrial complex II activity compared to those in the euthymic phase, with a significant negative correlation between the Hamilton Depression Rating Scale score and mitochondrial complex II activity [50], providing a strong link between reduced mitochondrial function and current bipolar depressive phase
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