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In wild-type mice, FGF21 treatment increases hepatic transcription of the canonical oxidative stress response and antioxidant genes Sod2 (superoxide dismutase 2), Cat (catalase), Gpx1 (glutathione peroxidase 1), Sirt1 (sirtuin), and Foxo3 (forkhead box transcription factor 3) (151)
We needed a form that could efficiently support glutathione levels where they're needed most
for instance, drugs designed to modulate brain mitochondria must penetrate the BBB, which can be achieved through nanoparticle conjugation or chemical modification to enhance lipophilicity [19]
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