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There was also an improvement in the levels of low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, and triglycerides in participants who received retatrutide compared to placebo, which did not show improvement
A February 2026 study in the Journal of Clinical Endocrinology & Metabolism found an 11% higher fragility fracture risk in older adults with Type 2 diabetes using GLP-1 medications versus those using other diabetes medications - though this was a retrospective study documenting association, not proven causation
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Semaglutide can affect your central nervous system because it can cross the blood-brain barrier to affect areas of the brain involved in appetite regulation and nausea perception, potentially contributing to nausea and even vomiting
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