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However, sustained high levels of circulating insulin may conversely exert a negative influence on cognitive function, due to prolonged peripheral hyperinsulinemia down-regulates insulin receptors at the blood-brain barrier (BBB) and reduces insulin transport into the brain, leading to brain insulin resistance (BIR) (1719)
To speed up absorption drink on an empty stomach, and wait at least 15 minutes before eating
PGI2, prostaglandin I2
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A low-carbohydrate or ketogenic diet can be beneficial for blood glucose management in type 2 diabetes, and is supported by Diabetes UK and NICE guideline NG28
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