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The subcutaneous schedules above are research-use practice conventions [18] , so findings should be interpreted according to route and formulation

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Mice exposed to chronic unpredictable mild stress (CUMS) for 6 weeks showed increased hypothalamic corticotropin-releasing hormone concentrations, elevated corticosterone levels and increased blood ammonia, which corresponded with anxiety-like behaviors, demonstrating HPA axis involvement in anxiety pathogenesis (Jia et al., 2024)

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Patients who underwent repeated surgery (n = 2), developed severe medical complications (n = 2), and whose relatives refused treatment (n = 3) were also excluded

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