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The gastrointestinal lining contains abundant GLP-1 receptors that respond to medication exposure by altering fluid and electrolyte balance within the bowel
Dietary supplements are regulated differently than pharmaceutical drugs under FDA oversight
For more on the FDAs policy on these compounded drugs, click here
Its unique mechanism of action, mimicking GLP-1, sets it apart from traditional methods
Licensing (Marketing Authorisation): The MHRA has approved: Semaglutide (Wegovy) for adults with BMI 30 kg/m or BMI 27 kg/m with at least one weight-related comorbidity Liraglutide (Saxenda) with similar BMI criteria NHS Access (NICE Guidance): According to NICE guidance (TA664 for semaglutide), NHS-funded treatment is more restricted and typically available for adults with: BMI 35 kg/m with at least one weight-related comorbidity (such as hypertension, type 2 diabetes, dyslipidaemia, obstructive sleep apnoea, or cardiovascular disease) For individuals from Black, Asian, and minority ethnic backgrounds, lower BMI thresholds may apply, recognising that these populations face increased metabolic risk at lower BMI levels