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Nicotinamide N-methyltransferase (NNMT): a novel therapeutic target for metabolic syndrome in aging
Comparative analyses indicate tirzepatide often produces faster, larger weight loss than semaglutide in many patients
5c and Extended Data Fig
How it works: Ferulic acid is metabolized by gut bacteria into forms that activate GLP-1-producing cells in the intestines (and even fat tissue via bitter taste receptors)
The triple-receptor mechanism produces significant gastrointestinal effects, particularly nausea, when doses increase too quickly
doi: 10.1038/nrn3856 91 SharmaG
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