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The Aspergillus fumigatus transcriptional regulator AfYap1 represents the major regulator for defense against reactive oxygen intermediates but is dispensable for pathogenicity in an intranasal mouse infection model
So, part of the approach to addressing some of these very complicated patients is working in a partnership with them, because we dont have the answers
Presented for research literature review only Ramage PI et al
Notably, these cells were previously telomerase-negative, meaning the enzyme had normally been switched off
Meanwhile, single-cell RNA sequencing (scRNA-seq) has revealed that stem-like cell populations with elevated OXPHOS activity contribute to drug resistance and metastatic potential, providing direct evidence for the cellular basis of metabolic heterogeneity in CRC [166, 167]
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