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Phase 2 trial data (Jastreboff et al., NEJM 2023) demonstrated average weight reductions of approximately 1724% over 48 weeks notably higher than currently approved GLP-1 receptor agonists such as semaglutide, though direct comparisons are limited by differences in trial populations and designs
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Existing bald areas may not fully regrow with medication alone
The animals were kept in a controlled environment with stable temperature and humidity under a 12-hour light/dark cycle
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Conditions including acute hepatitis, cirrhosis, non-alcoholic fatty liver disease (NAFLD), and liver cancer have all been associated with elevated serum B12
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