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This hypothesis was supported in a recent study with a 20-year follow-up, which found chronic low dose exposure to POPs predicted excess adiposity, dyslipidemia, and insulin resistance among participants without diabetes, in a U-shaped fashion (characteristic of endocrine disruption)

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Thus, while KD exerts multiple beneficial effects on the microbiota and gutbrain axis, its limitations must be carefully considered when evaluating its therapeutic potential in PD

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