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A large observational study using electronic health records (TriNetX database) analyzed nearly 90,000 patients with type 2 diabetes treated with GLP-1 receptor agonists

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Any drop in haemoglobin and rise in the urea:creatinine ratio is very indicative of an upper GI bleed, as digested haemoglobin produces urea as a by-product and is readily absorbed by the intestine Ensure all patients with melena have a Group and Save performed, with those with any significant haemoglobin drop or haemodynamic instability having blood products cross-matched too

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