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Notably, GLP-1R-LepR co-expressing cells proved to be crucial targets of newly synthesized GLP-1/leptin dual agonists, which create a negative energy balance and assist the action of leptin [75]

doi: 10.1111/bjd.12886

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Taking an epithelium of order 1 mm thick we arrive to a maximum size for radius of order 1.6 cm if the nevus is entirely located above the basal membrane and if only one primitive melanoma cell is present in the lesion permanently