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The STEP 1 trial (Wilding et al., New England Journal of Medicine 2021) used this exact titration in the semaglutide 2.4 mg arm and found that 86.4% of participants reached the 2.4 mg maintenance dose by week 20

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By increasing the bioavailability of these compounds in the skin, the amount of melanin produced is increased and the body produces a natural tan quicker

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Other big questions remain, like whether the drug could also help people with other types of liver disease

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