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To view or add a comment, sign in Results from a phase 2 study evaluating an investigational treatment for Alpha-1 Antitrypsin Deficiency (#AATD), achieved all primary and key secondary endpoints

Patients with certain genetic profiles may experience more pronounced rebound effects after stopping, while others maintain results more easily

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This is the mechanistic basis for claims about mood and neurological effects, but the chain of inference from rodent dopamine modulation to human mood benefit is long and unvalidated

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Elimination is considered to occur only from the central compartment, because the liver and kidneys are highly vascularized tissues