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They were initially defined as secretory GPX, but later studies have shown that both enzymes are localized to the endoplasmic reticulum and are necessary enzymes involved in the oxidative folding of endoplasmic reticulum proteins (Figure 8)

OXPHOS requires the presence of oxygen, and oxygen conversion into water occurs in the inner mitochondrial membrane

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Burning or stinging that intensifies rather than diminishes

Presented for research literature review only Hasansulama W et al

However, it is unclear exactly which isoform acts in cardiomyocytes and how it exerts its anti-ferroptosis effect, which requires further study