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In India, CKDu hotspots are particularly concentrated in southeastern coastal districts such as Tamil Nadu, Puducherry, and the Uddanam region of Andhra Pradesh [43, 44]
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The superoxide anion production is counteracted by the capacity of the antioxidant defence system, which is determined by a dynamic interaction between individual plasma and cell components (including retinol, -carotene, -tocopherol, coenzyme Q10, glutathione, etc.), and the activity of several antioxidant enzymes
