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This class of medications has grown rapidly in the last couple of years, as both diabetes treatments like Ozempic, Mounjaro and Trulicity, and weight loss drugs, like Wegovy and Zepbound have found increased use

Eating below 1,200 calories (women) or 1,500 calories (men) for extended periods risks metabolic adaptation, nutrient deficiency, and accelerated muscle loss

As we expected, either GLP-1R blockade or PKA inhibition partially eliminated the protective effects of the combined therapy on endothelial function

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Results can be long-lasting with continued maintenance of a healthy lifestyle.

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