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Joint discomfort associated with B12 supplementation is uncommon and not listed amongst the recognised adverse effects in the Summary of Product Characteristics (SmPC) for licensed B12 preparations or in the British National Formulary (BNF)
B12 shots contain about 100 micrograms of B12, which is roughly 40 times the recommended daily value for an average healthy adult (2.4 micrograms)
2003 Nov;36(8):585-90
If they think they may have a B12 deficiency, a blood test can determine this
Follow standard laboratory storage practices appropriate for research materials to help maintain integrity over time
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