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Using plasma concentrations uncorrected for endogenous levocarnitine, the mean distribution half life was 0.585 hours and the mean apparent terminal elimination half life was 17.4 hours

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For example, this should include time-of-day chronotherapeutic studies that examine whether exogenous melatonin is most beneficial to be given to patients in relation to endogenous rhythms

Jian Xu, [email protected] These authors have contributed equally to this work and share first authorship This article was submitted to Developmental Endocrinology, a section of the journal Frontiers in Endocrinology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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