glp 1 gut microbiota GLP‐1 agonists and the microbiome: A bidirectional relationship - Kamath - 2026 - British Journal of Clinical Pharmacology Gut microbiota as a target

But, there are important caveats

LC also affects mitochondrial activity by boosting mitochondrial biogenesis and decreasing oxidative stress

When stratified by comparator groups, the pooled estimate was most favorable in monotherapy trials versus placebo (SMD 2.41, 95% CI 4.43 to 0.39), whereas the add-on designs versus the same background treatment (SMD 0.65, 95% CI 1.85 to 0.55), head-to-head comparisons versus another drug (SMD 0.19, 95% CI 0.84 to 0.45), and add-on designs versus placebo (SMD 0.65, 95% CI 1.35 to 0.06) showed more modest estimates and did not provide clear evidence of a between-group difference overall (p=0.21)

Role of Zinc and Selenium in Oxidative Stress and Immunosenescence (PMC, 2020) Darstellung der Bedeutung von Zink und Selen fr Immunfunktion und antioxidative Abwehr im Alterungsprozess

Before & After *Individual Results May Vary*

Xiao Y, He Z, Li W, Chen D, Niu X, Yang X, Zeng W, Wang M, Qian Y, Su Y, et al