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These therapeutic strategies possess high selectivity, especially when activated by GSH localized in the tumor [80]
Myzak MC, Karplus PA, Chung F-L, Dashwood RH (2004) A Novel Mechanism of Chemoprotection by Sulforaphane: Inhibition of Histone Deacetylase
Disclosure The authors report no conflicts of interest in this work
Retatrutide is an investigational triple receptor agonist (GLP-1, GIP, glucagon) that remains unlicensed in the UK, with no MHRA approval, no NHS availability, and no BNF listing as of 20242025
Furthermore, CHAC2 also maintains pluripotency through a CHAC1-independent pathway by regulating the NRF2-GCL axis, thereby sustaining GSH biosynthesis and concurrently suppressing ROS production (Wang et al., 2017)
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