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136,137 Together, these features define resistance as a systems-level phenomenon, driven not by single mutations but by dynamic cellular and microenvironmental networks, necessitating integrated, multitargeted therapeutic strategies
Metformin is a safe and highly effective drug treatment for T2D and is the most commonly prescribed drug to treat the disorder
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Similarly, semaglutide for weight loss is titrated to a target subcutaneous dose of 2.4 mg/week, while its oral formulation -approved for T2DM management- is administered at 314 mg/day [39]
Clinical and epidemiological studies support sex difference in markers of IR in MDD showing that the prevalence of MDD is twice as higher in women than in men