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People with diabetic complications or cognitive disorders may require more alpha-lipoic acid
Copper is a required cofactor for lysyl oxidase (connective-tissue crosslinking), for superoxide dismutase (antioxidant defense), and for enzymes that support angiogenesis, so a molecule that delivers copper in a controlled, cell-usable form has a coherent reason to influence tissue remodeling and vascular biology
2.4 mg is the only dose taken into phase 3: 11.5% body weight over 68 weeks
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An imbalance in the intestinal flora induces vascular damage by activating macrophages, which promotes atherosclerosis progression, thereby increasing the risk of coronary heart disease (119)
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