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Cost-Effectiveness and Accessibility: A Practical Consideration Injections typically incur higher costs due to doctor visits and administration fees, while oral pills provide a more affordable and accessible option

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Johns Wort can accelerate clearance and diminish efficacy, whereas inhibitors like ketoconazole, clarithromycin, certain protease inhibitors, or excessive grapefruit intake may elevate serum estradiol and increase adverse-event risk