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Mild GI changes Community sources describe occasional loose stool or transient appetite shifts in the first 1-2 weeks of use, sometimes attributed to systemic anti-inflammatory effects rather than direct GI irritation

Fracture models showed faster bone healing, improved callus formation, better bone mineral density, and quicker return of mechanical strength

It met its primary endpoint, showing stabilisation of gait speed on the 10-metre walk test at week 61 in participants aged five and over (least squares mean difference 33.3%, p=0.041)

In Using Mathematics to Understand Biological Complexity , 135178 (Springer, 2020)

thus, they are important components of safener effects (Brazier-Hicks et al., 2018)