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Subnormal alkaline phosphatase levels may indicate the presence of hypophosphatasia, Wilsons disease, deficiencies of divalent ions, or malnutrition

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Strong AHAs/BHAs (Glycolic, Salicylic Acid): Using these with kojic acid can lead to excessive exfoliation, leading to irritation, redness, and patchy pigmentation, especially if you have sensitive or dusky skin