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First, glutamate-cysteine ligase (GCL) links glutamate and cysteine to form -glutamyl cysteine (rate-limiting steps)
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112,113 Several clinical studies support the cardiovascular benefits of GLP-1 RAs, as there is evidence from meta-analyses of cardiovascular outcome trials illustrating that GLP-1 RA therapy lowers the risk of major adverse cardiovascular events by 14% and all-cause mortality by 12% in patients with T2D
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Xia N, Daiber A, Forstermann U, Li H
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