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Fowkes MM, Lalonde T, Yu L, Dhanvantari S, Kovacs MS, Luyt LG

16 At a time when 41.9% of the US population has obesity and cardiovascular disease accounting for 1 in every 5 deaths, the downstream implications of expanded insurance coverage and establishment of obesity as a modifiable risk factor could allow SELECT to stand as one of the most important events in public health since the turn of the century

Design and evaluation of peptide dual-agonists of GLP-1 and NPY2 receptors for glucoregulation and weight loss with mitigated nausea and emesis

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showed that the activation of ferroptosis by erastin increased the levels of lysosome-associated membrane protein 2a (LAMP2A) to promote CMA, which, in turn, triggered the degradation of GPX4