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It further impairs mitochondrial function by inducing hypophosphatemia, which contributes to organelle dysfunction

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doi: 10.3389/fendo.2025.1579457 Received 19 February 2025 Accepted 24 July 2025 Published 27 August 2025 Volume 16 - 2025 Edited by Shizhan Ma, Shandong Provincial Hospital Affiliated to Shandong First Medical University, China Reviewed by Huang Xiaofei, Nanjing University of Chinese Medicine, China Yaodong Wang, Yangzhou University, China Updates Copyright 2025 Fang, Ding, Wang and Teng

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Dose Titration We start patients at a conservative dose and titrate upward over the first 8 to 12 weeks based on response and tolerance

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The aqueous environment enables hydrolysis, oxidation, and aggregation

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