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These measures help maintain the compounds stability under approved conditions
Starting with lower doses and slower titration improves tolerance for both medications
Another study reported that, in children with fever, the area under the serum concentration-time curve (AUC) increased by 1344% from first dose to steady state implying that paracetamol may accumulate in this patient group although no hepatotoxicity was demonstrated [48]
Vieira is a Family Physician licensed to practice in Brazil, with over two decades of experience in both Brazilian and UK healthcare systems
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