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Gingival mesenchymal stem cell exosomes (GMSC-Exo) reprogram macrophage metabolism from glycolysis to OXPHOS by suppressing HIF-1 signaling, thereby promoting M2 polarization in a periodontitis model (308)
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Mast cells generate histamine in an allergic reaction, and when suffering from MCAS, the levels can rise in such a way that the symptoms are exacerbated, mainly: Because the symptoms of MCAS and histamine intolerance are similar, it will be hard to tell the difference between the two
In addition, a study using LPS-exposed RAW264.7 macrophages and a DSS-triggered colitis murine model demonstrated that GLP-1 attenuates inflammatory responses by inhibiting the phosphorylation process of AKT/NF-B and MAPK signal-transducing molecules under in vitro and in vivo circumstances, respectively [219]
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