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Toxicity of methionine in humans
The area postrema, which lacks a blood-brain barrier, detects circulating signals and can trigger nausea
At full therapeutic doses, roughly 40% of patients experience GI side effects severe enough to consider stopping
Although GLP-1RAs confer anti-inflammatory and glycemic benefits, persistent reductions in nutrient inflow and delayed gastric emptying may limit the availability of amino acids and micronutrients required for tissue maintenance and redox homeostasis
Avoiding fat is also important, so eating grilled or sauted meat is better than choosing breaded or fried options
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