Common side effects include: Gastrointestinal issues: Nausea, vomiting, constipation, and abdominal pain Injection site reactions: Redness, swelling, and pain Systemic issues: Fatigue, indigestion, heartburn, belching, and hair loss More severe side effects include: Thyroid problems: Medullary thyroid cancer and pancreatitis with severe, persistent abdominal pain Gallbladder problems with symptoms such as upper abdominal pain, fever, jaundice, or clay-colored stools Increased risk of hypoglycemia with symptoms such as dizziness, sweating, confusion, and shakiness Severe vomiting that leads to dehydration and kidney problems Mental health concerns such as depression and suicidal thoughts Vision changes from rapid changes in blood glucose levels Some patients should not use Zepbound, such as those who have or are at risk for medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2

The longest cardiovascular outcome trials follow patients for around 5 to 6 years and show consistent cardiovascular benefit and acceptable tolerability
If the medication is well tolerated and you see excellent results, medication can be a very useful as a tool after, for example weight loss surgery, when the patient moves into the maintenance phase of their long-term postoperative plan
This is one of the most common reasons people begin asking why GLP-1 medications are not working for them
The identification of subgroups that are most likely to benefit from GLP-1RAs could be guided by biomarkers, and cardiac imaging may help determine whether the advantages of GLP-1RAs extend beyond the metabolic or obesity phenotypes
GLP-1 receptor agonists are medications that work with the bodys natural systems to help regulate appetite, blood sugar and digestion