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If the pen was sealed and kept at room temperature for only 8 hours, the medication likely remains mostly potent, though some degradation may have begun

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Rybelsus (semaglutide) tablets: prescribing information

Certain medications can contribute to leg cramps, including loop and thiazide diuretics, beta-agonists, and statins (which more commonly cause diffuse myalgia rather than focal cramps)

This is when you will lose the most weight