Cystine deficiency can also mitigate the tumor growth in EGFR mutated NSCLC xenografts (Poursaitidis et al., 2017)
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Acylcarnitine subsequently increases the activity of mitochondrial electron transport chain complexes and mitochondrial OXPHOS by promoting the acetylation of H3K27
Glutathione is a natural antioxidant that helps protect cells from damage
The sequestration of cystine within lysosomes may deplete cytosolic cysteine, which is essential for glutathione synthesis, leading to impaired redox homeostasis [144, 146]