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5 In the SUSTAIN series of clinical trials, semaglutide consistently demonstrated significant reductions in HbA1c levels compared to placebo and other diabetes medications, such as sitagliptin 6 , exenatide ER 7 , and dulaglutide 8
2 In a press release issued at the time, Prime Therapeutics senior vice president of specialty and clincal solutions Steve Cutts said, Prime's second-year study on the real-world impact of GLP-1 drugs for obesity showed both low adherence and increased costs of care
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Consistency between batches is excellent
plastic vials vary between those composed of polystyrene and those made of polypropylene
However, compared with native GLP-1, which is rapidly degraded and has a short half-life of approximately 2 min, semaglutide has been structurally modified by the addition of a hydrophilic spacer and a fatty acid side chain, allowing reversible binding to albumin [36]
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