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It also activates p38 MARK, ERK1/2 cascade, and JNK cascade, which promotes apoptosis and inflammation (Potilinski et al., 2020)

Receptors are expressed in multiple nuclei of the hypothalamus and brainstem, where central mechanisms suppress appetite and regulate energy intake and expenditure (7174)

Secondary endpoints at the 12mg dose included: fasting insulin reduction of 41%, triglyceride reduction of ~40%, waist circumference reduction of 18.5 cm, and meaningful improvements in liver fat fraction on MRI in a subset of participants

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