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2016 Nov 10;375(19):1834-1844

Tirzepatide has been shown to have a slightly stronger impact on appetite suppression compared to semaglutide, potentially leading to more significant weight loss

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Tirzepatide targets two gut hormones: GIP GLP-1 Both influence appetite, insulin release, and energy balance, and both act on brain circuits that: Regulate reward Motivation Satiety GLP-1 receptor activity reaches areas of the brain involved in mood and cognition, and experimental work suggests GLP-1 agonists can reduce brain inflammation and support neurons