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The combined quinone redox glutathione metabolism model can be used to simulate experimentally challenging scenarios such as potential redox cycling toxicity, while providing a platform from which quinone exposure and concentration toxicity experiments may be guided

Furthermore, anti-TNF--treated inflammatory bowel disease (IBD) patients display a reduced PD risk compared with the untreated IBD patients, providing indirect evidence that long-term TNF- suppression may mitigate PD development [190]

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