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The areas thus obtained for standard TMA were correlated with the area of the internal standard, and the resulting ratio (TMA/D9-TMA or TMAO/D9-TMAO) was correlated with the standard concentration to verify the range of linearity of the response, which was in the range from 25 nM to 100 M
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This suggests that the mGIPR-Ab/GLP-1 peptideantibody conjugate may be able to directly act on GIPR and GLP-1R in the AP to trigger c-Fos activation in the brain
Proposed mechanisms include: Enhancing cellular communication Supporting local growth factor expression Modulating nitric oxide pathways for circulation While promising, its important to note that human trials remain limited , and more research is needed before drawing definitive conclusions
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