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The Cochrane systematic review by Mulvaney et al
doi: 10.1001/jama.2023.3371 [PubMed] 37405349 Giordani AS, Baritussio A, Vicenzetto C, Peloso-Cattini MG, Pontara E, Bison E, Fraccaro C, Basso C, Iliceto S, Marcolongo R, Caforio ALP
For some, its about health
The article says patients with higher BMI or altered fat distribution may see different absorption profiles at each site, and lists skin thickness at the abdomen as variable by BMI
The effects tend to build gradually through daily activity rather than appearing suddenly
Not maximum eating occasions
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