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Several possible side effects and limitations deserve attention: Patients with pre-existing kidney disease should avoid high doses

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The role behind the scenes of Tregs and Th17s in Hashimoto's thyroiditis: Toward a pivotal role of FOXP3 and BACH2

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For example, the exact reductive mechanisms for both Prx1 and Gpx2 remain a matter of debate, particularly regarding the specific roles of glutathione, glutaredoxins, thioredoxins and thioredoxin reductase (Pedrajas et al , 2000, 2010, 2016