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288297, 2018 [46] A

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[1] Onset of deficiency may take years to develop

Patients beginning tirzepatide therapy should understand that results develop progressively over several months, with the medication requiring gradual dose escalation to optimize efficacy while minimizing gastrointestinal side effects

These STI1 regions of UBQLN2 also reportedly bind to other components, such as Hsp70, that are crucial for the protein quality control function of UBQLN2 (Hjerpe et al, 2016