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Menopause marks the point when menstrual periods stop permanently
Compared to untreated MAFLD rats, those treated with metformin exhibited metabolic changes in the phosphatidylinositol signaling pathway, which plays a critical role in regulating various cellular functions, including cell survival, proliferation, and apoptosis, and is crucial for the development of hepatic fat accumulation 74
Multiple methodologies exist to evaluate the antiproliferative, and anti-cancer properties of polyphenols (469, 470)
used high-glucose treatment in SH-SY5Y cells to mimic diabetic neuropathy and explored the effect of the GLP-1R agonist exendin-4 on diabetic neuropathy (48)
Beyond these systemic benefits, evidence now suggests that GLP-1 receptor activation has direct effects on hepatocytes, contributing to reductions in steatosis, inflammation, and fibrosis
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