By the end of the 40-week trial, the estimated changes for A1C were -1.86% for those receiving 1 mg of semaglutide and -2.01%, -2.24%, and -2.30% for those receiving the respective tirzepatide doses of 5 mg, 10 mg, and 15 mg
If additional glycemic control is needed after at least four weeks at 0.5 mg, the dose may be increased to 1 mg weekly
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However, no cases of hypoglycemia were reported in phase 2 trials
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